GPR37 (gpr37_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR37
GENE
GPR37
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prosaposin receptor GPR37, Endothelin B receptor-like protein 1, ETBR-LP-1, G-protein coupled receptor 37, Parkin-associated endothelin receptor-like receptor, PAELR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
A
|
P
|
G
|
A
|
L
|
L
|
A
|
R
|
10 |
M
|
S
|
R
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
20 |
K
|
V
|
S
|
A
|
S
|
S
|
A
|
L
|
G
|
V
|
30 |
A
|
P
|
A
|
S
|
R
|
N
|
E
|
T
|
C
|
L
|
40 |
G
|
E
|
S
|
C
|
A
|
P
|
T
|
V
|
I
|
Q
|
50 |
R
|
R
|
G
|
R
|
D
|
A
|
W
|
G
|
P
|
G
|
60 |
N
|
S
|
A
|
R
|
D
|
V
|
L
|
R
|
A
|
R
|
70 |
A
|
P
|
R
|
E
|
E
|
Q
|
G
|
A
|
A
|
F
|
80 |
L
|
A
|
G
|
P
|
S
|
W
|
D
|
L
|
P
|
A
|
90 |
A
|
P
|
G
|
R
|
D
|
P
|
A
|
A
|
G
|
R
|
100 |
G
|
A
|
E
|
A
|
S
|
A
|
A
|
G
|
P
|
P
|
110 |
G
|
P
|
P
|
T
|
R
|
P
|
P
|
G
|
P
|
W
|
120 |
R
|
W
|
K
|
G
|
A
|
R
|
G
|
Q
|
E
|
P
|
130 |
S
|
E
|
T
|
L
|
G
|
R
|
G
|
N
|
P
|
T
|
140 |
A
|
L
|
Q
|
L
|
F
|
L
|
Q
|
I
|
S
|
E
|
150 |
E
|
E
|
E
|
K
|
G
|
P
|
R
|
G
|
A
|
G
|
160 |
I
|
S
|
G
|
R
|
S
|
Q
|
E
|
Q
|
S
|
V
|
170 |
K
|
T
|
V
|
P
|
G
|
A
|
S
|
D
|
L
|
F
|
180 |
Y
|
W
|
P
|
R
|
R
|
A
|
G
|
K
|
L
|
Q
|
190 |
G
|
S
|
H
|
H
|
K
|
P
|
L
|
S
|
K
|
T
|
200 |
A
|
N
|
G
|
L
|
A
|
G
|
H
|
E
|
G
|
W
|
210 |
T
|
I
|
A
|
L
|
P
|
G
|
R
|
A
|
L
|
A
|
220 |
Q
|
N
|
G
|
S
|
L
|
G
|
E
|
G
|
I
|
H
|
230 |
E
|
P
|
G
|
G
|
P
|
R
|
R
|
G
|
N
|
S
|
240 |
T
|
N
|
R
|
R
|
V
|
R
|
L
|
K
|
N
|
P
|
250 |
TM1 | |||||||||
F
|
Y
|
P
|
L
|
T
|
Q
|
E
|
S
|
Y
|
G
|
260 |
A
|
Y
|
A
|
V
|
M
|
C
|
L
|
S
|
V
|
V
|
270 |
I
|
F
|
G
|
T
|
G
|
I
|
I
|
G
|
N
|
L
|
280 |
A
|
V
|
M
|
C
|
I
|
V
|
C
|
H
|
N
|
Y
|
290 |
ICL1 | TM2 | ||||||||
Y
|
M
|
R
|
S
|
I
|
S
|
N
|
S
|
L
|
L
|
300 |
A
|
N
|
L
|
A
|
F
|
W
|
D
|
F
|
L
|
I
|
310 |
I
|
F
|
F
|
C
|
L
|
P
|
L
|
V
|
I
|
F
|
320 |
ECL1 | |||||||||
H
|
E
|
L
|
T
|
K
|
K
|
W
|
L
|
L
|
E
|
330 |
TM3 | |||||||||
D
|
F
|
S
|
C
|
K
|
I
|
V
|
P
|
Y
|
I
|
340 |
E
|
V
|
A
|
S
|
L
|
G
|
V
|
T
|
T
|
F
|
350 |
T
|
L
|
C
|
A
|
L
|
C
|
I
|
D
|
R
|
F
|
360 |
ICL2 | |||||||||
R
|
A
|
A
|
T
|
N
|
V
|
Q
|
M
|
Y
|
Y
|
370 |
TM4 | |||||||||
E
|
M
|
I
|
E
|
N
|
C
|
S
|
S
|
T
|
T
|
380 |
A
|
K
|
L
|
A
|
V
|
I
|
W
|
V
|
G
|
A
|
390 |
L
|
L
|
L
|
A
|
L
|
P
|
E
|
V
|
V
|
L
|
400 |
ECL2 | |||||||||
R
|
Q
|
L
|
S
|
K
|
E
|
D
|
L
|
G
|
F
|
410 |
S
|
G
|
R
|
A
|
P
|
A
|
E
|
R
|
C
|
I
|
420 |
I
|
K
|
I
|
S
|
P
|
D
|
L
|
P
|
D
|
T
|
430 |
TM5 | |||||||||
I
|
Y
|
V
|
L
|
A
|
L
|
T
|
Y
|
D
|
S
|
440 |
A
|
R
|
L
|
W
|
W
|
Y
|
F
|
G
|
C
|
Y
|
450 |
F
|
C
|
L
|
P
|
T
|
L
|
F
|
T
|
I
|
T
|
460 |
C
|
S
|
L
|
V
|
T
|
A
|
R
|
K
|
I
|
R
|
470 |
ICL3 | |||||||||
K
|
A
|
E
|
K
|
A
|
C
|
T
|
R
|
G
|
N
|
480 |
TM6 | |||||||||
K
|
R
|
Q
|
I
|
Q
|
L
|
E
|
S
|
Q
|
M
|
490 |
N
|
C
|
T
|
V
|
V
|
A
|
L
|
T
|
I
|
L
|
500 |
Y
|
G
|
F
|
C
|
I
|
I
|
P
|
E
|
N
|
I
|
510 |
C
|
N
|
I
|
V
|
T
|
A
|
Y
|
M
|
A
|
T
|
520 |
TM7 | |||||||||
G
|
V
|
S
|
Q
|
Q
|
T
|
M
|
D
|
L
|
L
|
530 |
N
|
I
|
I
|
S
|
Q
|
F
|
L
|
L
|
F
|
F
|
540 |
K
|
S
|
C
|
V
|
T
|
P
|
V
|
L
|
L
|
F
|
550 |
H8 | |||||||||
C
|
L
|
C
|
K
|
P
|
F
|
S
|
R
|
A
|
F
|
560 |
M
|
E
|
C
|
C
|
C
|
C
|
C
|
C
|
E
|
E
|
570 |
C-term | |||||||||
C
|
I
|
Q
|
K
|
S
|
S
|
T
|
V
|
T
|
S
|
580 |
D
|
D
|
N
|
D
|
N
|
E
|
Y
|
T
|
T
|
E
|
590 |
L
|
E
|
L
|
S
|
P
|
F
|
S
|
T
|
I
|
R
|
600 |
R
|
E
|
M
|
S
|
T
|
F
|
A
|
S
|
V
|
G
|
610 |
T
|
H
|
C
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
prosaptide
STRUCTURE MODELS
STRUCTURES
No structures available